Fresh analysis suggests that people who stop using popular slimming jabs like Wegovy and Mounjaro may regain lost weight much more quickly than those who halt traditional diet and exercise regimens.
Findings released in a leading medical journal shows that while overweight people frequently drop substantial amounts of their total mass while undergoing treatment, the weight comes back at an average rate of 0.8 kg per month after stopping.
"Users using these medications must be informed of the danger of quick rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
This pace of recovery suggests a reversion to starting mass within about 18 months.
Weighing Therapies
The study, which reviewed dozens of trials involving over 9,000 of participants, compared the outcomes of GLP-1 agonists with other pills.
Scientists note that people who lose weight through lifestyle changes alone usually see a slower weight regain—around 0.1 kg a month—after stopping.
Understanding the Fast Rebound
Experts propose the mechanism of the jabs is key to understanding the amplified weight return.
The injections mimic a body's own chemical called GLP-1, which moderates appetite.
"Sustained high doses of GLP-1 concentrations far above than the body's typical production might result in the body to produce less of its own natural hormone, and could diminish sensitivity to its effects," said Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this GLP-1 'fix' results in hunger is no longer kept in check, making overeating much more probable."
A Lifelong Condition?
Medical guidelines advise the jabs for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Professionals contend that, due to the significant potential of relapse, the treatment might need to be life-long.
This opinion is echoed by pharmaceutical companies, who say that the findings "emphasize the long-term character of excess weight," akin to managing diseases like hypertension.
Patient Testimonies
Users who have stopped the medication describe a powerful resurgence of cravings.
"I experienced a switch activating and I was suddenly starving," described one woman.
This challenge is exacerbated if individuals have not adopted permanent dietary or behavioural modifications during therapy.
Widespread Use
Recent estimates suggest that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with demand remaining high.
- Adoption is more common among women compared to men.
- The middle-aged age group shows the highest usage rates.
- Many access the medications through private healthcare rather than the NHS.
Finally, researchers caution that while the jabs are effective agents for weight loss, they are not a standalone solution and long-term success hinges on integrated behavioural changes.
